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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in older adults with a body mass index (BMI) of greater than 27, given that they also are afflicted by weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder in addition to being an aid to quitting smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that includes a reduced-calorie eating and working out, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had a typical weight loss of four years old.1% rather than participants who were given placebos) throughout a 12- month period, while an outside study involving patients with diabetes type 2 had a normal weight loss of 2% over treatment with placebo at twelve months.

Using two separate drugs to lose weight naturally can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight loss and the those who go through it one should err to the side of caution and let the FDA do its job and demand some research be done in order that the public knows the side effects and dangers of the medications before we take them. Keep in mind that drug companies will be in business to generate money and that they would say anything to keep people on the medications.

Researchers found out that participants taking this drug for any year, lost excess weight within 4 weeks and have kept the load off during the entire 56 weeks with the study. Contrave is really a combination from the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which can be made up of many active ingredient, which might make them more efficient and safer.

Combo-pilling may be the newest fad or in addition to this the newest in the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is becoming popular could be the fact that by right now there are no long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be licensed by the FDA.

Seizures really are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug also can raise blood pressure levels and pulse rate, and mustn't be used in people who have a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high hypertension, and also by you are not heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients with a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients for the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

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